Posts tagged with: Population genomics

Journal Safari: Whole Genomes, Read as Exomes

Published on September 30, 2026 6 min read

Journal Safari #6. A Nature Genetics paper ran exome-style burden tests on 708,956 whole genomes for BMI and type 2 diabetes. Whole-genome sequencing turned out to be a better exome, worth about a fifth more signal, and the most interesting biology in it, a kidney effect of IRS2, rests on a few dozen carriers.

Journal Safari: What Do You Buy by Sequencing Half a Million Whole Genomes?

Published on July 23, 2026 11 min read

Journal Safari #2. The UK Biobank just finished whole-genome sequencing all 490,640 participants. I read the resource paper to answer one question: what does WGS actually buy you over the array and exomes we already had — and who pays the storage bill afterward?

Journal Safari Bioinformatics Population genomics