Oct 14, 2026
Journal Safari #7. DeepMind's AlphaGenome reads a megabase of DNA, predicts thousands of genomic tracks, and matches or beats the strongest competing model on 25 of 26 variant tests, mostly by a little. It calls the direction of a variant's effect far better than the size, which makes it a scanner rather than a verdict, and a decent preview of where AI in biology is right now.
Oct 4, 2026
I wanted a cheap AI model to pick the one biology preprint worth reading out of hundreds. With no hand-labelled answers to check against, I graded 20 cheap model setups on how closely they matched an expensive one, Claude Sonnet 5, for under $3. The best match came from outside Sonnet's family, and the setup I now run costs about $2 a year.
Sep 30, 2026
Journal Safari #6. A Nature Genetics paper ran exome-style burden tests on 708,956 whole genomes for BMI and type 2 diabetes. Whole-genome sequencing turned out to be a better exome, worth about a fifth more signal, and the most interesting biology in it, a kidney effect of IRS2, rests on a few dozen carriers.