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Microbial ecology spent twenty years learning that in low-biomass samples, the thing you measure is partly your reagents. Single-cell has the same exposure, most of the same tooling gaps, and none of the same scar tissue — and the field is moving into exactly the regime where it starts to matter.
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Journal Safari #3. Pan-human Azimuth puts 27 million cells from 23 tissues on one annotation tree, then classifies them with a model 70× smaller than the foundation model I read in July — and wins. The contribution is not the model. It is the labels.
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Kicking off Journal Safari, my biweekly close-read of one recent paper. First up: CellVQ, a 500-million-parameter single-cell foundation model that squashes every cell into a discrete code — and the peer reviews that quietly agreed with my doubts.
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